![]() We detected with QCM-D the interaction of VPP with the nitrogenous bases sequences that comprise the minimal promoter region of both genes CAT and SOD. We also used molecular modeling (Docking) to determine the interaction between the peptide VPP and the minimal promoter region of both genes. This study analyzes the interaction between VPP and specific domains in the minimal promoter region of genes SOD and CAT in blood samples of obese children using a type QCM-D piezoelectric biosensor. Currently there are no reports on the possible interaction of VPP with the enzymes superoxide dismutase (SOD) and catalase (CAT), the main regulators of oxidative stress. It has also been shown that oral administration of VPP produces an anti-inflammatory effect in adipose tissue of mice models. It's been reported that the milk derived peptide (VPP) prevents the progress of hypertension in different animal models and human beings with mild hypertension. ![]() ![]() It has been reported that bioactive peptides play a very important role in the regulation of physiological functions such as oxidative stress, hypertension, cancer and inflammation. Bioactive peptides are biomolecules involved in very diverse mechanisms in vivo. ![]()
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